Description | Getting started | Design a CRM trial with DTP as a calibration tool | CRM Design Considerations | 1. Clinical Parameters | 2. Model Specification Parameters | 3. Practical Considerations | Simulations: assess operating characteristics of the proposed CRM design | Simulation Results | DTP for initial cohorts | Displaying DTP in a table format | Displaying DTP as a flow diagram | Trial Conduct with DTP | Model Updates with accumulated information | Update of Dose Toxicity Curves | Update DTP for Subsequent Cohorts | DTP table for Cohorts 3 to 6 | DTP flow diagram for Cohorts 3 to 5 | References
Package: dtpcrm 0.1.3
Xiaoran Lai
dtpcrm: Dose Transition Pathways for Continual Reassessment Method
Provides the dose transition pathways (DTP) to project in advance the doses recommended by a model-based design for subsequent patients (stay, escalate, deescalate or stop early) using all the accumulated toxicity information; See Yap et al (2017) <doi:10.1158/1078-0432.CCR-17-0582>. DTP can be used as a design and an operational tool and can be displayed as a table or flow diagram. The 'dtpcrm' package also provides the modified continual reassessment method (CRM) and time-to-event CRM (TITE-CRM) with added practical considerations to allow stopping early when there is sufficient evidence that the lowest dose is too toxic and/or there is a sufficient number of patients dosed at the maximum tolerated dose.
Authors:
dtpcrm_0.1.3.tar.gz
dtpcrm_0.1.3.zip(r-4.7-any)dtpcrm_0.1.3.zip(r-4.6-any)dtpcrm_0.1.3.zip(r-4.5-any)
dtpcrm_0.1.3.tgz(r-4.6-any)dtpcrm_0.1.3.tgz(r-4.5-any)
dtpcrm_0.1.3.tar.gz(r-4.7-any)dtpcrm_0.1.3.tar.gz(r-4.6-any)
dtpcrm_0.1.3.tgz(r-4.6-emscripten)
manual.pdf |manual.html✨
DESCRIPTION |NEWS
card.svg |card.png
dtpcrm/json (API)
| # Install 'dtpcrm' in R: |
| install.packages('dtpcrm', repos = c('https://icr-epat.r-universe.dev', 'https://cloud.r-project.org')) |
Bug tracker:https://github.com/icr-epat/dtpcrm/issues
Last updated from:b26f636a99. Checks:9 OK. Indexed: yes.
| Target | Result | Time | Files | Syslog |
|---|---|---|---|---|
| linux-devel | OK | 130 | ||
| source / vignettes | OK | 198 | ||
| linux-release | OK | 129 | ||
| macos-release | OK | 180 | ||
| macos-oldrel | OK | 181 | ||
| windows-devel | OK | 71 | ||
| windows-release | OK | 69 | ||
| windows-oldrel | OK | 63 | ||
| wasm-release | OK | 137 |
Exports:applied_crmapplied_crm_simapplied_titecrmapplied_titecrm_simapplied_titecrmts_simcalculate_dtpsdtpflowplot_crmstop_for_consensus_reachedstop_for_excess_toxicity_empiricstop_for_excess_toxicity_logisticstop_for_sample_sizesummary_crm
Readme and manuals
Help Manual
| Help page | Topics |
|---|---|
| Execute the CRM | applied_crm |
| Simulate CRM trials using specified design options | applied_crm_sim |
| Execute the TITE-CRM | applied_titecrm |
| Simulate TITE-CRM trials using specified design options | applied_titecrm_sim |
| Simulate TITE-CRM trials using specified design options | applied_titecrmts_sim |
| Produce the Dose Transition Pathways | calculate_dtps |
| Produce DTP flow diagram | dtpflow |
| Plot of posterior estimates from the CRM | plot_crm |
| Stopping for consensus | stop_for_consensus_reached |
| Stopping for excess toxicity - Empiric method | stop_for_excess_toxicity_empiric |
| Stopping for excess toxicity - Logistic method | stop_for_excess_toxicity_logistic |
| Stopping for sample size reached | stop_for_sample_size |
| Provide a summary of applied_crm output | summary_crm |