Package: dtpcrm Type: Package Title: Dose Transition Pathways for Continual Reassessment Method Version: 0.1.3 Authors@R: c(person("Christina", "Yap", email = "yapchristina17@gmail.com", role = c("aut")), person("Daniel", "Slade", email = "D.Slade@bham.ac.uk", role = c("aut")), person("Kristian", "Brock", email = "k.brock@bham.ac.uk", role = c("aut")), person("Yi", "Pan", email = "ypan1988@gmail.com", role = c("aut")), person("Xiaoran", "Lai", email = "xiaoran.lai@icr.ac.uk", role = c("cre"), comment = c(ORCID = "0000-0002-7364-3993"))) Description: Provides the dose transition pathways (DTP) to project in advance the doses recommended by a model-based design for subsequent patients (stay, escalate, deescalate or stop early) using all the accumulated toxicity information; See Yap et al (2017) . DTP can be used as a design and an operational tool and can be displayed as a table or flow diagram. The 'dtpcrm' package also provides the modified continual reassessment method (CRM) and time-to-event CRM (TITE-CRM) with added practical considerations to allow stopping early when there is sufficient evidence that the lowest dose is too toxic and/or there is a sufficient number of patients dosed at the maximum tolerated dose. License: GPL (>= 2) Encoding: UTF-8 Imports: diagram, dfcrm Suggests: knitr, rmarkdown, testthat VignetteBuilder: knitr RoxygenNote: 7.3.3 Repository: https://icr-epat.r-universe.dev Date/Publication: 2026-10-01 10:10:35 UTC RemoteUrl: https://github.com/icr-epat/dtpcrm RemoteRef: HEAD RemoteSha: b26f636a99246257fc46eb770edf3a8ec26568d5 NeedsCompilation: no Packaged: 2026-10-01 11:03:36 UTC; root Author: Christina Yap [aut], Daniel Slade [aut], Kristian Brock [aut], Yi Pan [aut], Xiaoran Lai [cre] (ORCID: ) Maintainer: Xiaoran Lai