# ------------------------------------------------ # CITATION.cff file created with {cffr} R package # See also: https://docs.ropensci.org/cffr/ # ------------------------------------------------ cff-version: 1.2.0 message: 'To cite package "dtpcrm" in publications use:' type: software license: GPL-2.0-or-later title: 'dtpcrm: Dose Transition Pathways for Continual Reassessment Method' version: 0.1.3 doi: 10.32614/CRAN.package.dtpcrm abstract: Provides the dose transition pathways (DTP) to project in advance the doses recommended by a model-based design for subsequent patients (stay, escalate, deescalate or stop early) using all the accumulated toxicity information; See Yap et al (2017) . DTP can be used as a design and an operational tool and can be displayed as a table or flow diagram. The 'dtpcrm' package also provides the modified continual reassessment method (CRM) and time-to-event CRM (TITE-CRM) with added practical considerations to allow stopping early when there is sufficient evidence that the lowest dose is too toxic and/or there is a sufficient number of patients dosed at the maximum tolerated dose. authors: - family-names: Yap given-names: Christina email: yapchristina17@gmail.com - family-names: Slade given-names: Daniel email: D.Slade@bham.ac.uk - family-names: Brock given-names: Kristian email: k.brock@bham.ac.uk - family-names: Pan given-names: Yi email: ypan1988@gmail.com - family-names: Lai given-names: Xiaoran email: xiaoran.lai@icr.ac.uk orcid: https://orcid.org/0000-0002-7364-3993 repository: https://icr-epat.r-universe.dev commit: b26f636a99246257fc46eb770edf3a8ec26568d5 date-released: '2026-10-01' contact: - family-names: Lai given-names: Xiaoran email: xiaoran.lai@icr.ac.uk orcid: https://orcid.org/0000-0002-7364-3993