{ "_id": "6abe3ee899f7aa8c6aa54423", "Package": "dtpcrm", "Type": "Package", "Title": "Dose Transition Pathways for Continual Reassessment Method", "Version": "0.1.3", "Authors@R": "c(person(\"Christina\", \"Yap\", email = \"yapchristina17@gmail.com\",\nrole = c(\"aut\")),\nperson(\"Daniel\", \"Slade\", email = \"D.Slade@bham.ac.uk\",\nrole = c(\"aut\")),\nperson(\"Kristian\", \"Brock\", email = \"k.brock@bham.ac.uk\",\nrole = c(\"aut\")),\nperson(\"Yi\", \"Pan\", email = \"ypan1988@gmail.com\",\nrole = c(\"aut\")),\nperson(\"Xiaoran\", \"Lai\", email = \"xiaoran.lai@icr.ac.uk\",\nrole = c(\"cre\"),\ncomment = c(ORCID = \"0000-0002-7364-3993\")))", "Description": "Provides the dose transition pathways (DTP) to project in\nadvance the doses recommended by a model-based design for\nsubsequent patients (stay, escalate, deescalate or stop early)\nusing all the accumulated toxicity information; See Yap et al\n(2017) . DTP can be used as\na design and an operational tool and can be displayed as a\ntable or flow diagram. The 'dtpcrm' package also provides the\nmodified continual reassessment method (CRM) and time-to-event\nCRM (TITE-CRM) with added practical considerations to allow\nstopping early when there is sufficient evidence that the\nlowest dose is too toxic and/or there is a sufficient number of\npatients dosed at the maximum tolerated dose.", "License": "GPL (>= 2)", "Encoding": "UTF-8", "VignetteBuilder": "knitr", "RoxygenNote": "7.3.3", "Repository": "https://icr-epat.r-universe.dev", "Date/Publication": "2026-10-01 10:10:35 UTC", "RemoteUrl": "https://github.com/icr-epat/dtpcrm", "RemoteRef": "HEAD", "RemoteSha": "b26f636a99246257fc46eb770edf3a8ec26568d5", "NeedsCompilation": "no", "Packaged": { "Date": "2026-10-01 11:03:36 UTC", "User": "root" }, "Author": "Christina Yap [aut],\nDaniel Slade [aut],\nKristian Brock [aut],\nYi Pan [aut],\nXiaoran Lai [cre] (ORCID: )", "Maintainer": "Xiaoran Lai ", "_user": "icr-epat", "_type": "src", "_file": "dtpcrm_0.1.3.tar.gz", "_fileid": "https://r2.ropensci.org/b84e9ab1c01a2e9ffa5bb4b130042dfe2cb4200ddda73133806cc7955ca3ee84", "_filesize": 480985, "_sha256": "b84e9ab1c01a2e9ffa5bb4b130042dfe2cb4200ddda73133806cc7955ca3ee84", "_expires": "2027-01-09T11:07:18.000Z", "_created": "2026-10-01T11:03:36.000Z", "_published": "2026-10-01T11:07:20.626Z", "_jobs": [ { "job": 110338816905, "time": 130, "config": "linux-devel-x86_64", "r": "4.7.0", "check": "OK", "artifact": "11156745779" }, { "job": 110338817070, "time": 129, "config": "linux-release-x86_64", "r": "4.6.1", "check": "OK", "artifact": "11156576325" }, { "job": 110338816907, "time": 181, "config": "macos-oldrel-arm64", "r": "4.5.3", "check": "OK", "artifact": "11156491904" }, { "job": 110338816875, "time": 180, "config": "macos-release-arm64", "r": "4.6.1", "check": "OK", "artifact": "11156397277" }, { "job": 110337671570, "time": 198, "config": "source", "r": "4.6.1", "check": "OK", "artifact": "11156128988" }, { "job": 110338816891, "time": 137, "config": "wasm-release", "r": "4.6.0", "check": "OK", "artifact": "11156204051" }, { "job": 110338816903, "time": 71, "config": "windows-devel-x86_64", "r": "4.7.0", "check": "OK", "artifact": "11155354857" }, { "job": 110338816951, "time": 63, "config": "windows-oldrel-x86_64", "r": "4.5.3", "check": "OK", "artifact": "11156303443" }, { "job": 110338816902, "time": 69, "config": "windows-release-x86_64", "r": "4.6.1", "check": "OK", "artifact": "11156551516" } ], "_host": "GitHub-Actions", "_buildurl": "https://github.com/r-universe/icr-epat/actions/runs/36852623352", "_status": "success", "_upstream": "https://github.com/icr-epat/dtpcrm", "_commit": { "id": "b26f636a99246257fc46eb770edf3a8ec26568d5", "author": "Xiaoran Lai ", "committer": "GitHub ", "message": "Prepare 0.1.3 for CRAN submission (#4)\n\nFix the Lost braces Rd NOTE in applied_crm() by using \\eqn{}, re-document\nwith roxygen2 7.3.3, remove LazyData (no data directory), use the\ncanonical doi form in DESCRIPTION, and use https and canonical CRAN URLs\nin the README. Add NEWS.md and cran-comments.md.\n\n* Change maintainer to Xiaoran Lai\n* Bump version to 0.1.3\n\n0.1.2 was a GitHub-only version and was never released on CRAN, so the\nCRAN update goes from 0.1.1 to 0.1.3. Split NEWS.md into 0.1.3 and the\nGitHub-only 0.1.2, and explain the version gap in cran-comments.md.", "time": 1790849435 }, "_maintainer": { "name": "Xiaoran Lai", "email": "xiaoran.lai@icr.ac.uk", "login": "xlai", "orcid": "0000-0002-7364-3993", "description": "", "uuid": 6449900 }, "_distro": "resolute", "_registered": true, "_dependencies": [ { "package": "diagram", "role": "Imports" }, { "package": "dfcrm", "role": "Imports" }, { "package": "knitr", "role": "Suggests" }, { "package": "rmarkdown", "role": "Suggests" }, { "package": "testthat", "role": "Suggests" } ], "_owner": "icr-epat", "_selfowned": true, "_usedby": 0, "_updates": [ { "week": "2026-40", "n": 2 } ], "_tags": [], "_stars": 1, "_contributors": [ { "user": "christinayap", "count": 51, "uuid": 48917791 }, { "user": "ypan1988", "count": 6, "uuid": 8374747 }, { "user": "xlai", "count": 2, "uuid": 6449900 } ], "_userbio": { "uuid": 202140365, "type": "organization", "name": "ICR Clinical Trials and Statistics Unit - Early Phase and Adaptive Trials Team", "followers": 3, "description": "This is where we host most of the scientific programmes and tools created by ICR-CTSU Early Phase and Adaptive Trials Team" }, "_downloads": { "count": 334, "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/dtpcrm" }, "_devurl": "https://github.com/icr-epat/dtpcrm", "_rbuild": "4.6.1", "_assets": [ "extra/citation.cff", "extra/citation.html", "extra/citation.json", "extra/citation.txt", "extra/contents.json", "extra/dtpcrm.html", "extra/manual.pdf", "extra/NEWS.html", "extra/NEWS.txt", "extra/readme.html", "extra/readme.md" ], "_homeurl": "https://github.com/icr-epat/dtpcrm", "_realowner": "icr-epat", "_cranurl": true, "_releases": [ { "version": "0.1.0", "date": "2019-04-10" }, { "version": "0.1.1", "date": "2019-08-20" } ], "_exports": [ "applied_crm", "applied_crm_sim", "applied_titecrm", "applied_titecrm_sim", "applied_titecrmts_sim", "calculate_dtps", "dtpflow", "plot_crm", "stop_for_consensus_reached", "stop_for_excess_toxicity_empiric", "stop_for_excess_toxicity_logistic", "stop_for_sample_size", "summary_crm" ], "_help": [ { "page": "applied_crm", "title": "Execute the CRM", "topics": [ "applied_crm" ] }, { "page": "applied_crm_sim", "title": "Simulate CRM trials using specified design options", "topics": [ "applied_crm_sim" ] }, { "page": "applied_titecrm", "title": "Execute the TITE-CRM", "topics": [ "applied_titecrm" ] }, { "page": "applied_titecrm_sim", "title": "Simulate TITE-CRM trials using specified design options", "topics": [ "applied_titecrm_sim" ] }, { "page": "applied_titecrmts_sim", "title": "Simulate TITE-CRM trials using specified design options", "topics": [ "applied_titecrmts_sim" ] }, { "page": "calculate_dtps", "title": "Produce the Dose Transition Pathways", "topics": [ "calculate_dtps" ] }, { "page": "dtpflow", "title": "Produce DTP flow diagram", "topics": [ "dtpflow" ] }, { "page": "plot_crm", "title": "Plot of posterior estimates from the CRM", "topics": [ "plot_crm" ] }, { "page": "stop_for_consensus_reached", "title": "Stopping for consensus", "topics": [ "stop_for_consensus_reached" ] }, { "page": "stop_for_excess_toxicity_empiric", "title": "Stopping for excess toxicity - Empiric method", "topics": [ "stop_for_excess_toxicity_empiric" ] }, { "page": "stop_for_excess_toxicity_logistic", "title": "Stopping for excess toxicity - Logistic method", "topics": [ "stop_for_excess_toxicity_logistic" ] }, { "page": "stop_for_sample_size", "title": "Stopping for sample size reached", "topics": [ "stop_for_sample_size" ] }, { "page": "summary_crm", "title": "Provide a summary of applied_crm output", "topics": [ "summary_crm" ] } ], "_readme": "https://github.com/icr-epat/dtpcrm/raw/HEAD/README.md", "_rundeps": [ "dfcrm", "diagram", "shape" ], "_vignettes": [ { "source": "dtpcrm_vignettev02.Rmd", "filename": "dtpcrm_vignettev02.html", "title": "dtpcrm: Dose Transition Pathways with Continual Reassessment Method", "author": "Christina Yap, Daniel Slade", "engine": "knitr::rmarkdown", "headings": [ "Description", "Getting started", "Design a CRM trial with DTP as a calibration tool", "CRM Design Considerations", "1. 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Practical Considerations", "Simulations: assess operating characteristics of the proposed CRM design", "Simulation Results", "DTP for initial cohorts", "Displaying DTP in a table format", "Displaying DTP as a flow diagram", "Trial Conduct with DTP", "Model Updates with accumulated information", "Update of Dose Toxicity Curves", "Update DTP for Subsequent Cohorts", "DTP table for Cohorts 3 to 6", "DTP flow diagram for Cohorts 3 to 5", "References" ], "created": "2019-04-03 16:28:43", "modified": "2019-08-10 00:11:17", "commits": 5 } ], "_score": 4, "_indexed": true, "_nocasepkg": "dtpcrm", "_universes": [ "icr-epat", "xlai" ], "_binaries": [ { "r": "4.7.0", "os": "linux", "version": "0.1.3", "date": "2026-10-01T11:05:45.000Z", "distro": "resolute", "commit": "b26f636a99246257fc46eb770edf3a8ec26568d5", "fileid": "https://r2.ropensci.org/726f0ae187fad9107a70a5763b3319d36e73858ce10e8e0988dbb56cd60441ce", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/icr-epat/actions/runs/36852623352" }, { "r": "4.6.1", "os": "linux", "version": "0.1.3", "date": "2026-10-01T11:05:45.000Z", "distro": "resolute", "commit": "b26f636a99246257fc46eb770edf3a8ec26568d5", "fileid": "https://r2.ropensci.org/845df033c9fbebbc52f10d7f6b15eb35d03c7f5691460b54233899e3957d1297", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/icr-epat/actions/runs/36852623352" }, { "r": "4.5.3", "os": "mac", "version": "0.1.3", "date": "2026-10-01T11:06:12.000Z", "commit": "b26f636a99246257fc46eb770edf3a8ec26568d5", "fileid": "https://r2.ropensci.org/3dfdacf88ef4c5fab6e06dcd6b369b375724975d19a7d89cf6049a7f1e4fa1ba", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/icr-epat/actions/runs/36852623352" }, { "r": "4.6.1", "os": "mac", "version": "0.1.3", "date": "2026-10-01T11:06:03.000Z", "commit": "b26f636a99246257fc46eb770edf3a8ec26568d5", "fileid": "https://r2.ropensci.org/465582d43f9de2c39370797aa69ea5adeec6ec308d8e8b3bf166321199e138e2", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/icr-epat/actions/runs/36852623352" }, { "r": "4.6.0", "os": "wasm", "version": "0.1.3", "date": "2026-10-01T11:06:07.000Z", "commit": "b26f636a99246257fc46eb770edf3a8ec26568d5", "fileid": "https://r2.ropensci.org/ba919182752a8717ff426a7eb190c0cf954c8b936fff0bc780bc8f07bbd52b73", "status": "success", "buildurl": "https://github.com/r-universe/icr-epat/actions/runs/36852623352" }, { "r": "4.7.0", "os": "win", "version": "0.1.3", "date": "2026-10-01T11:04:40.000Z", "commit": "b26f636a99246257fc46eb770edf3a8ec26568d5", "fileid": "https://r2.ropensci.org/93924fd25a3991f1d7f304be1229897cc47c0552ffc4d677c94d150998b83844", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/icr-epat/actions/runs/36852623352" }, { "r": "4.5.3", "os": "win", "version": "0.1.3", "date": "2026-10-01T11:04:37.000Z", "commit": "b26f636a99246257fc46eb770edf3a8ec26568d5", "fileid": "https://r2.ropensci.org/e7b013116f95b7e0417ed055937a64190c2401ccbb2b0cf7478b49b7a82d3bf4", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/icr-epat/actions/runs/36852623352" }, { "r": "4.6.1", "os": "win", "version": "0.1.3", "date": "2026-10-01T11:04:42.000Z", "commit": "b26f636a99246257fc46eb770edf3a8ec26568d5", "fileid": "https://r2.ropensci.org/33080aea30247451898858e2667bb9544dd12935cdf184d90d9452db8e2da6b5", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/icr-epat/actions/runs/36852623352" } ] }