https://icr-epat.r-universe.devRecent package updates in icr-epatR-universehttps://github.com/icr-epat.pnghttps://icr-epat.r-universe.devThu, 01 Oct 2026 10:10:35 GMTxiaoran.lai@icr.ac.uk (Xiaoran Lai)Provides the dose transition pathways (DTP) to project in advance the doses recommended by a model-based design for subsequent patients (stay, escalate, deescalate or stop early) using all the accumulated toxicity information; See Yap et al (2017) <doi:10.1158/1078-0432.CCR-17-0582>. DTP can be used as a design and an operational tool and can be displayed as a table or flow diagram. The 'dtpcrm' package also provides the modified continual reassessment method (CRM) and time-to-event CRM (TITE-CRM) with added practical considerations to allow stopping early when there is sufficient evidence that the lowest dose is too toxic and/or there is a sufficient number of patients dosed at the maximum tolerated dose.https://github.com/r-universe/icr-epat/actions/runs/36852623352Thu, 01 Oct 2026 10:10:35 GMTdtpcrm0.1.3successhttps://icr-epat.r-universe.devhttps://github.com/icr-epat/dtpcrmdtpcrm_vignettev02.Rmddtpcrm_vignettev02.htmldtpcrm: Dose Transition Pathways with Continual Reassessment Method2019-04-03 16:28:432019-08-10 00:11:17