Package: dtptite 0.1.0

Xiaoran Lai

dtptite: Dose Transition Pathways for Time-to-Event Dose-Finding Designs

Implements the Dose Transition Pathways (DTP) look-ahead strategy for time-to-event phase I dose-finding clinical trials with delayed or pending toxicity outcomes. Provides a DTP decorator for the 'escalation' framework, supporting both TITE-CRM (model-based) and TITE-BOIN (model-assisted) base designs.

Authors:Xiaoran Lai [aut, cre], The Institute of Cancer Research [cph], National Institute for Health and Care Research [fnd]

dtptite_0.1.0.tar.gz
dtptite_0.1.0.zip(r-4.7-any)dtptite_0.1.0.zip(r-4.6-any)dtptite_0.1.0.zip(r-4.5-any)
dtptite_0.1.0.tgz(r-4.6-any)dtptite_0.1.0.tgz(r-4.5-any)
dtptite_0.1.0.tar.gz(r-4.7-any)dtptite_0.1.0.tar.gz(r-4.6-any)
dtptite_0.1.0.tgz(r-4.6-emscripten)
manual.pdf |manual.html✨
DESCRIPTION |NEWS
card.svg |card.png
dtptite/json (API)

# Install 'dtptite' in R:

install.packages('dtptite', repos = c('https://icr-epat.r-universe.dev', 'https://cloud.r-project.org'))

Bug tracker:https://github.com/icr-epat/dtptite/issues

On CRAN:

3.70 score 1 scripts 12 exports 115 dependencies

Last updated from:c8d6b69994. Checks:9 OK. Indexed: yes.

Target	Result	Time
linux-devel	OK	271
source / vignettes	OK	336
linux-release	OK	299
macos-release	OK	189
macos-oldrel	OK	274
windows-devel	OK	289
windows-release	OK	208
windows-oldrel	OK	296
wasm-release	OK	199

Exports:apply_dtp dtp_projected_dose dtp_should_wait dtp_wait_events dtp_wait_summary dtp_wait_time get_boin_tite scenario_mtd set_dtp_queue_size stop_for_beta_binomial_toxicity time_to_first_mtd tite_patient_samples

Dependencies:abind arrayhelpers backports base64enc BH binom bit bit64 BOIN brio bslib cachem callr checkmate cli clipr coda cpp11 crayon desc dfcrm DiagrammeR diffobj digest distributional dplyr escalation evaluate farver fastmap fontawesome fs generics ggdist ggplot2 glue gridExtra gtable gtools highr hms htmltools htmlwidgets igraph inline Iso isoband jquerylib jsonlite knitr labeling lattice lifecycle loo magrittr MASS Matrix matrixStats memoise mime mvtnorm numDeriv otel pillar pkgbuild pkgconfig pkgload posterior praise prettyunits processx progress ps purrr quadprog QuickJSR R6 rappdirs RColorBrewer Rcpp RcppEigen RcppParallel readr rlang rmarkdown rprojroot rstan rstantools rstudioapi S7 sass scales StanHeaders stringi stringr svUnit tensorA testthat tibble tidybayes tidyr tidyselect tinytex trialr tzdb utf8 vctrs viridis viridisLite visNetwork vroom waldo withr xfun yaml

Citation

Development and contributors

Readme and manuals

Help Manual

Help page	Topics
Apply the DTP look-ahead to a TITE selector factory.	apply_dtp
Projected dose after waiting.	dtp_projected_dose
Should the trialist wait before dosing the next cohort?	dtp_should_wait
Raw DTP wait event log from simulated trials.	dtp_wait_events
Per-trial DTP wait summary from simulated trials.	dtp_wait_summary
Minimum wait time before the dose recommendation changes.	dtp_wait_time
Create a TITE-BOIN dose-finding selector.	get_boin_tite
Plot the cumulative incidence of reaching the MTD.	plot.time_to_first_mtd
True MTD of a simulated scenario.	scenario_mtd
Set the waiting-room capacity for DTP simulation.	set_dtp_queue_size
Stop for excessive toxicity using a Beta-Binomial conjugate posterior.	stop_for_beta_binomial_toxicity
Summarise time-to-first-MTD across replicates.	summary.time_to_first_mtd
Time until the first patient is dosed at the true MTD.	time_to_first_mtd
Create patient samples with realistic TITE DLT timing.	tite_patient_samples